Apoquel Vs Benadryl [All You Need To Know]

Do you know the difference between Apoquel and Benadryl?
Have you ever wondered which one is better?
Today, we’ll be discussing the pros and cons of each medication.

Apoquel is a prescription medication used to treat itch and inflammation in dogs. Benadryl is an over-the-counter medication that can be used to treat itch in dogs. Apoquel is more effective than Benadryl in treating itch and inflammation, but Benadryl is less expensive and has fewer side effects.

The pros and cons of Apoquel and Benadryl will be discussed in order to help you make the best decision for your dog.

Table of Contents

What is the difference between Apoquel and Benadryl?

Apoquel and Benadryl are two medication options for treating allergies in dogs. Apoquel is an oral medication that works by inhibiting the release of histamines, which are the chemicals that cause allergic reactions.

Benadryl is an antihistamine that can be given orally or topically and works by blocking the action of histamines. Both medications can be effective in treating allergies, but they work in different ways.

Which one is more effective for treating allergies?

There are many different types of allergies and each person reacts differently to various allergy treatments. Some people find that over-the-counter antihistamines work well for their allergies, while others may need a prescription-strength medication.

Some people may also need to avoid certain triggers, such as pollen or pet dander, to keep their allergies under control.

Are there any side effects associated with either medication?

There are a few potential side effects associated with both medications. For example, both medications can cause drowsiness, so it is important not to drink alcohol or operate heavy machinery while taking either medication.

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Additionally, both medications can cause dry mouth, so it is important to drink plenty of fluids while taking either medication. Finally, both medications can cause constipation, so it is important to eat a high-fiber diet and drink plenty of fluids while taking either medication.

How do I know if either of these medications is right for me?

The best way to determine if a medication is right for you is to speak with your physician. He or she can review your medical history and make recommendations based on your specific needs.

Is Benadryl better than Apoquel for dogs?

There are a few key differences between Benadryl and Apoquel that may make one or the other a better choice for your dog, depending on his individual needs. Benadryl is an antihistamine, while Apoquel is an anti-inflammatory medication.

This means that Benadryl is useful for treating allergies, while Apoquel is more effective against inflammatory conditions such as arthritis. Benadryl is also available in both pill and liquid form, while Apoquel only comes in pill form.

Can I give my dog Apoquel and Benadryl together?

Yes, you can give your dog Apoquel and Benadryl together. Apoquel is a medication that is used to treat allergic reactions in dogs, and Benadryl is a medication that is used to treat allergies in humans. Both medications work by blocking the action of histamine, which is a substance that is released during an allergic reaction.

Is there an alternative to Apoquel?

Apoquel has been a go-to drug for treating allergies in dogs for years, but recent reports of serious side effects have many dog owners looking for alternatives. The good news is that there are several options available.

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Antihistamines are the most common type of allergy medication. They work by blocking the histamine receptors, which prevents the histamine from binding and causing an allergic reaction. Some common antihistamines include diphenhydramine (Benadryl), cetirizine (Zyrtec), and loratadine (Claritin).

Corticosteroids are another type of allergy medication that can be effective in treating allergies. Corticosteroids work by reducing inflammation and suppressing the immune system. Some common corticosteroids include prednisone, dexamethasone, and hydrocortisone.

Allergy shots (immunotherapy) are also an option for treating allergies, though they are typically reserved for people with severe allergies who have not had success with other treatments. Allergy shots work by slowly exposing the person to increasing levels of the allergen, which eventually leads to the person becoming less sensitive to the allergen.

A new type of drug called dupilumab (Dupixent) has recently been approved by the FDA for the treatment of eczema. Dupilumab works by blocking the action of interleukin-4 (IL-4) and interleukin-13 (IL-13), two proteins that are involved in the development of allergic reactions.

As you can see, there are several options available for treating allergies. Talk to your doctor or allergist to find out which treatment is right for you.


The debate between Apoquel and Benadryl is one that has been going on for some time. There are pros and cons to both medications, and it ultimately comes down to personal preference. Apoquel is a newer medication that is specifically designed to treat allergies in dogs, while Benadryl is a more general antihistamine that can be used for a variety of purposes.

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Apoquel is generally considered to be more effective than Benadryl, but it is also more expensive. Benadryl is a generic medication that is widely available, while Apoquel is only available through veterinarians.

If your dog is suffering from allergies, speak to your veterinarian about which medication is right for them.